For research use only. Not for therapeutic Use.
Y16 (Cat No.: I003533) is a small-molecule inhibitor that selectively targets the RhoA–GEF-H1 interaction, disrupting a key signaling pathway involved in cytoskeletal organization, cell migration, and inflammation. By inhibiting this interaction, Y16 reduces RhoA activation and downstream effects such as stress fiber formation and cell contractility. It is widely used in cancer, fibrosis, and neurobiology research to study RhoA-mediated signaling. Y16 offers a valuable tool for exploring the role of RhoA in pathological processes and for developing potential therapeutics targeting Rho GTPase pathways.
| CAS Number | 429653-73-6 |
| Molecular Formula | C24H20N2O3 |
| Purity | ≥95% |
| Target | MAPK/ERK Pathway |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C24H20N2O3/c1-17-7-5-9-19(13-17)16-29-21-12-6-8-18(14-21)15-22-23(27)25-26(24(22)28)20-10-3-2-4-11-20/h2-15H,16H2,1H3,(H,25,27)/b22-15+ |
| InChIKey | ITMLWGWTDWJSRZ-PXLXIMEGSA-N |
| SMILES | O=C(/C1=CC2=CC=CC(OCC3=CC=CC(C)=C3)=C2)NN(C4=CC=CC=C4)C1=O |
| Reference | </br>1:Purification and characterization of a low-temperature hydroxylamine oxidase from heterotrophic nitrifier Acinetobacter sp. Y16. Zhang SM, Li WG, Zhang DY, Huang XF, Qin W, Sha CQ.Biomed Environ Sci. 2014 Jul;27(7):515-22. doi: 10.3967/bes2014.004. PMID: 25073910 Free Article</br>2:Ammonium removal by a novel oligotrophic Acinetobacter sp. Y16 capable of heterotrophic nitrification-aerobic denitrification at low temperature. Huang X, Li W, Zhang D, Qin W.Bioresour Technol. 2013 Oct;146:44-50. doi: 10.1016/j.biortech.2013.07.046. Epub 2013 Jul 18. PMID: 23911816 </br>3:Structural characterization and antioxidant properties of an exopolysaccharide produced by the mangrove endophytic fungus Aspergillus sp. Y16. Chen Y, Mao W, Tao H, Zhu W, Qi X, Chen Y, Li H, Zhao C, Yang Y, Hou Y, Wang C, Li N.Bioresour Technol. 2011 Sep;102(17):8179-84. doi: 10.1016/j.biortech.2011.06.048. Epub 2011 Jun 17. PMID: 21733681 </br>4:Inhibitory effects of costunolide isolated from Laurus nobilis on IgE-induced degranulation of mast cell-like RBL-2H3 cells and the growth of Y16 pro-B cells. Kim TJ, Nam KW, Kim B, Lee SJ, Oh KB, Kim KH, Mar W, Shin J.Phytother Res. 2011 Sep;25(9):1392-7. doi: 10.1002/ptr.3553. Epub 2011 Jun 14. PMID: 21674633 </br>5:Escherichia coli mutant Y16 is a double mutant carrying thermosensitive ftsH and ftsI mutations. Begg KJ, Tomoyasu T, Donachie WD, Khattar M, Niki H, Yamanaka K, Hiraga S, Ogura T.J Bacteriol. 1992 Apr;174(7):2416-7. PMID: 1551860 Free PMC Article |
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