For research use only, not for therapeutic use.
Yangonin(Cat No.:I003759)is one of the primary active compounds found in the kava plant (Piper methysticum), traditionally used for its calming and anxiolytic effects. It is known for its interaction with the brain’s CB1 cannabinoid receptors, which are involved in mood regulation and anxiety. Yangonin also possesses potential neuroprotective and antioxidant properties, making it of interest in neurological research. While it contributes to the psychoactive effects of kava, Yangonin has been studied for its non-addictive profile and possible therapeutic applications in stress management and cognitive health.
Catalog Number | I003759 |
CAS Number | 500-62-9 |
Synonyms | 4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one |
Molecular Formula | C15H14O4 |
Purity | ≥95% |
Solubility | 10 mM in DMSO |
Storage | -20°C |
IUPAC Name | 4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one |
InChI | InChI=1S/C15H14O4/c1-17-12-6-3-11(4-7-12)5-8-13-9-14(18-2)10-15(16)19-13/h3-10H,1-2H3/b8-5+ |
InChIKey | XLHIYUYCSMZCCC-VMPITWQZSA-N |
SMILES | COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=O)O2)OC |
Reference | <p style=/line-height:25px/> <br>[2]. Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB 1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9. <br>[3]. Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95. </p> |