YAP-TEAD Inhibitor 1 (Peptide 17)

• CAT Number: I015632
• CAS Number: 1659305-78-8
• Molecular Formula: C93H144ClN23O21S2
• Molecular Weight: 2019.86
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CCCCC1NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCSSCC(NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(C)NC(=O)C3CCCN3C1=O)C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCC(O)=O)C(N)=O)NC(=O)C(C

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.

Reference

[1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998.
[2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732.