YC-001

• CAT Number: I043928
• CAS Number: 748778-73-6
• Molecular Formula: C12H7ClO2S2
• Molecular Weight: 282.77
• Purity: ≥95%
• Synonyms: 3-(5-chlorothiophen-2-yl)-4-thiophen-2-yl-2H-furan-5-one
• InChI: InChI=1S/C12H7ClO2S2/c13-10-4-3-8(17-10)7-6-15-12(14)11(7)9-2-1-5-16-9/h1-5H,6H2
• InChIKey: RCLLWMPOHNZNAO-UHFFFAOYSA-N
• SMILES: C1C(=C(C(=O)O1)C2=CC=CS2)C3=CC=C(S3)Cl

YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration[1].
YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150–310%[1].
YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant[1].
YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC50 OF 0.98 µM[1].
YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells[1].
YC-001 (50, 200mg/kg; i.p.) protects Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration[1].
YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods[1].
YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity[1].

Reference

[1]. Chen Y, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976.
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