yGsy2p-IN-H23

• CAT Number: I045468
• CAS Number: 1269190-98-8
• Molecular Formula: C23H27N3O2
• Molecular Weight: 377.48
• Purity: ≥95%
• Synonyms: 2-methoxy-4-[3-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-phenylimidazol-4-yl]phenol
• InChI: InChI=1S/C23H27N3O2/c1-25-13-6-9-19(25)12-14-26-16-24-22(17-7-4-3-5-8-17)23(26)18-10-11-20(27)21(15-18)28-2/h3-5,7-8,10-11,15-16,19,27H,6,9,12-14H2,1-2H3
• InChIKey: YGPHAIXUDLLWHC-UHFFFAOYSA-N
• SMILES: CN1CCCC1CCN2C=NC(=C2C3=CC(=C(C=C3)O)OC)C4=CC=CC=C4

yGsy2p-IN-H23 is a potent and first-in-class inhibitor for yeast glycogen synthase 2 (yGsy2p) with an IC50 of 875 µM for human glycogen synthase 1 (hGYS1). yGsy2p-IN-H23 bounds within the uridine diphosphate glucose binding pocket of yGsy2p. yGsy2p-IN-H23 is used for the research of glycogen storage diseases (GSDs)[1].
yGsy2p-IN-H23 (compound H23) has IC50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 were 161 μM and 875 µM, respectively. yGsy2p-IN-H23 exhibits IC50 values of 280 µM and 263 µM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].

Reference

[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.
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