YH-53

• CAT Number: I038546
• CAS Number: 1471484-62-4
• Molecular Formula: C30H33N5O5S
• Molecular Weight: 575.68
• Purity: 98%
• Synonyms: YH-53; YH53; YH 53
• Target: SARS-CoV
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide
• InChI: InChI=1S/C30H33N5O5S/c1-16(2)13-22(34-29(39)23-15-18-19(32-23)8-6-9-24(18)40-3)28(38)33-21(14-17-11-12-31-27(17)37)26(36)30-35-20-7-4-5-10-25(20)41-30/h4-10,15-17,21-22,32H,11-14H2,1-3H3,(H,31,37)(H,33,38)(H,34,39)/t17-,21-,22-/m0/s1
• InChIKey: JBLLRCOZJMVOAE-HSQYWUDLSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)C2=NC3=CC=CC=C3S2)NC(=O)C4=CC5=C(N4)C=CC=C5OC

YH-53（Cat No.:I038546）is a selective, potent inhibitor of the protein kinase CK2 (casein kinase 2), a serine/threonine kinase involved in various cellular processes, including cell growth, survival, and apoptosis. By targeting CK2, YH-53 demonstrates potential in modulating pathways associated with cancer cell proliferation and survival. Its inhibition of CK2 activity can lead to the disruption of oncogenic signaling and offer a promising therapeutic avenue for cancer research. Ideal for studying kinase-related cellular processes and therapeutic development, YH-53 provides a valuable tool in drug discovery targeting CK2-dependent diseases.

Reference

1: Konno S, Kobayashi K, Senda M, Funai Y, Seki Y, Tamai I, Schäkel L, Sakata K, Pillaiyar T, Taguchi A, Taniguchi A, Gütschow M, Müller CE, Takeuchi K, Hirohama M, Kawaguchi A, Kojima M, Senda T, Shirasaka Y, Kamitani W, Hayashi Y. 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents. J Med Chem. 2021 Jul 27. doi: 10.1021/acs.jmedchem.1c00665. Epub ahead of print. PMID: 34313428.