YH239-EE

• CAT Number: I001402
• CAS Number: 1364488-67-4
• Molecular Formula: C₂₅H₂₇Cl₂N₃O₄
• Molecular Weight: 504.41
• Purity: ≥95%
• Synonyms: Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate
• Target: MDM-2/p53; E1/E2/E3 Enzyme; Apoptosis
• Solubility: DMSO: ≥ 55 mg/mL
• Storage: Desiccate at -20C
• IUPAC Name: ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
• InChI: InChI=1S/C25H27Cl2N3O4/c1-5-34-24(33)21-20(18-11-10-17(27)12-19(18)28-21)22(23(32)29-25(2,3)4)30(14-31)13-15-6-8-16(26)9-7-15/h6-12,14,22,28H,5,13H2,1-4H3,(H,29,32)
• InChIKey: OTUBDDRFPQLPKD-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(C2=C(N1)C=C(C=C2)Cl)C(C(=O)NC(C)(C)C)N(CC3=CC=C(C=C3)Cl)C=O

YH239-EE（Cat No.:I001402） is the ethyl ester derivative of the carboxylic acid compound YH239. It exhibits potent activity as a p53-MDM2 antagonist, meaning it interferes with the interaction between p53 and MDM2 proteins. By antagonizing MDM2, YH239-EE promotes the activation of p53, a tumor suppressor protein involved in regulating cell growth and apoptosis. Consequently, YH239-EE demonstrates the ability to induce apoptosis, or programmed cell death, highlighting its potential as an anticancer agent.

Reference

[1]. Huang Y, et al. Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol. 2014 Mar 21;9(3):802-11.