For research use only. Not for therapeutic Use.
YJC-10592 is a CC chemokine receptor 2 (CCR2) antagonist (IC50 value 1.12 μM), which also showed excellent inhibitory activity in the calcium assay (IC50 value 1.7 nM), and good potency in the chemotaxis assay (IC50 value 23 nM). In rats, YJC-10592 showed dose-dependent pharmacokinetics and low F value due to slower elimination and incomplete absorption.
KEYWORDS: YJC-10592 | supplier | CCR2 antagonist | YJC10592 | YJC 10592 | CAS [1226894-87-6] | Chemokine | Antagonist | Receptors | CCR2 | CCR 2
| Catalog Number | I047619 |
| CAS Number | 1226894-87-6 |
| Molecular Formula | C27H31ClF3N5O3 |
| Purity | ≥95% |
| IUPAC Name | N-[2-[[(3R)-1-[2-[4-(2-chlorobenzoyl)piperazin-1-yl]ethyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide |
| InChI | InChI=1S/C27H31ClF3N5O3/c28-23-7-2-1-6-22(23)26(39)36-14-12-34(13-15-36)10-11-35-9-8-21(18-35)33-24(37)17-32-25(38)19-4-3-5-20(16-19)27(29,30)31/h1-7,16,21H,8-15,17-18H2,(H,32,38)(H,33,37)/t21-/m1/s1 |
| SMILES | C1CN(C[C@@H]1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)CCN3CCN(CC3)C(=O)C4=CC=CC=C4Cl |
| Reference | JW Lim et al. Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2099-102.
ES Du et al. Pharmacokinetics of YJC-10592, a novel chemokine receptor 2 (CCR-2) antagonist, in rats. Arch Pharm Res. 2016 Jun;39(6):833-42. |
