For research use only. Not for therapeutic Use.
YKL-5-124 dose-dependently targets CDK7 in HAP1 and Jurkat cells as assessed by intracellular target engagement and IP kinase activity assays.
| Catalog Number | I038558 |
| Synonyms | YKL-05-124; YKL05124; YKL 05 124; |
| Molecular Formula | C28H34ClN7O3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-3-(4-acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide hydrochloride |
| InChI | InChI=1S/C28H33N7O3.ClH/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18;/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37);1H/t22-;/m1./s1 |
| InChIKey | JFUWMHSCJCCMPN-VZYDHVRKSA-N |
| SMILES | O=C(N(C1)C(C)(C)C2=C1C(NC(C3=CC=C(NC(C=C)=O)C=C3)=O)=NN2)N[C@@H](C4=CC=CC=C4)CN(C)C.[H]Cl |
| Reference | 1. Olson CM, Liang Y, Leggett A, Park WD, Li L, Mills CE, Elsarrag SZ, Ficarro SB, Zhang T, Düster R, Geyer M, Sim T, Marto JA, Sorger PK, Westover KD, Lin CY, Kwiatkowski N, Gray NS. Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype. Cell Chem Biol. 2019 Jun 20;26(6):792-803.e10. doi: 10.1016/j.chembiol.2019.02.012. Epub 2019 Mar 21. PubMed PMID: 30905681; PubMed Central PMCID: MC6588464. |
