YKL-05-124 HCl

• CAT Number: I038558
• Molecular Formula: C28H34ClN7O3
• Molecular Weight: 552.08
• Purity: 98%
• Synonyms: YKL-05-124; YKL05124; YKL 05 124
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (S)-3-(4-acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide hydrochloride
• InChI: InChI=1S/C28H33N7O3.ClH/c1-6-23(36)29-20-14-12-19(13-15-20)26(37)31-25-21-16-35(28(2,3)24(21)32-33-25)27(38)30-22(17-34(4)5)18-10-8-7-9-11-18;/h6-15,22H,1,16-17H2,2-5H3,(H,29,36)(H,30,38)(H2,31,32,33,37);1H/t22-;/m1./s1
• InChIKey: JFUWMHSCJCCMPN-VZYDHVRKSA-N
• SMILES: O=C(N(C1)C(C)(C)C2=C1C(NC(C3=CC=C(NC(C=C)=O)C=C3)=O)=NN2)N[C@@H](C4=CC=CC=C4)CN(C)C.[H]Cl

YKL-5-124(CAT: I038558) is a highly selective and potent inhibitor of cyclin-dependent kinase 7 (CDK7), a key regulator of transcription and cell cycle progression. It dose-dependently inhibits CDK7 activity in HAP1 and Jurkat cells, as demonstrated by intracellular target engagement and immunoprecipitation (IP) kinase activity assays. By targeting CDK7, YKL-5-124 disrupts transcriptional regulation and cell cycle control, making it a valuable tool in oncology research for studying transcription-dependent cancers. Its selective inhibition of CDK7 offers promising therapeutic potential for cancers driven by abnormal transcriptional activity, including leukemia and solid tumors.