YL-939

• CAT Number: I042361
• CAS Number: 3023925-68-7
• Molecular Formula: C25H26N6O
• Molecular Weight: 426.51
• Purity: ≥95%
• Synonyms: 8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-(1-piperidin-4-ylpyrazol-4-yl)imidazo[1,2-a]pyrazine
• InChI: InChI=1S/C25H26N6O/c1-2-4-18(5-3-1)22-16-30-17-23(20-14-27-31(15-20)21-6-10-26-11-7-21)28-24(25(30)29-22)19-8-12-32-13-9-19/h1-5,8,14-17,21,26H,6-7,9-13H2
• InChIKey: CQPPSOHBTWZQRN-UHFFFAOYSA-N
• SMILES: C1CNCCC1N2C=C(C=N2)C3=CN4C=C(N=C4C(=N3)C5=CCOCC5)C6=CC=CC=C6

YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis[1].
YL-939 (0.01-10 μM) efficiently protects cells from ferroptosis with IC50 values of 0.14 μM, 0.25 μM, 0.16 μM, 0.16 μM and 0.24 μM for HT-1080, Miapaca-2, Calu-1, HCT116 and SHSY5Y cells, respectively[1].
YL-939 (5 μM; 10 h; ES-2 cells) reduces the level of ROS in cytosolic, membrane lipids[1].
YL-939 (5 μM; 1-10 h; ES-2 cells) has a biological target of PHB2[1].
YL-939 (3 μM; 10 h; ES-2 cells) improves ferritin protein expression in a concentration-dependent manner and blocks autophagosomes/lysosomes, and hence inhibited ferritinophagy[1].
YL-939 (3 mg/kg; i.p.; single injection) ameliorates liver damage in an Acetaminophen (APAP)-induced acute liver injury mode[1]l.

Reference

[1]. Yang W, et, al. Non-classical ferroptosis inhibition by a small molecule targeting PHB2. Nat Commun. 2022 Dec 3;13(1):7473.
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