YM-254890

• CAT Number: I011844
• CAS Number: 568580-02-9
• Molecular Formula: C46H69N7O15
• Molecular Weight: 960.1
• Purity: ≥95%
• Target: P2Y Receptor
• Storage: RT
• InChIKey: QVYLWCAYZGFGNF-WBWCVGBTSA-N

YM-254890 (CAT: I011844) is a potent and selective inhibitor of Gq protein signaling. It functions by blocking the activation of Gq-coupled receptors, thus inhibiting downstream signaling pathways involved in cellular responses mediated by Gq proteins. YM-254890 has been shown to effectively inhibit Gq-mediated intracellular calcium mobilization and other cellular responses induced by various Gq-coupled receptors. Due to its specific targeting of Gq signaling, YM-254890 has potential applications in studying Gq-dependent signaling pathways and as a tool compound for investigating Gq protein-related diseases and drug discovery efforts targeting Gq-coupled receptors.

Reference

1: Kawasaki T, Taniguchi M, Moritani Y, Uemura T, Shigenaga T, Takamatsu H,
Hayashi K, Takasaki J, Saito T, Nagai K. Pharmacological properties of YM-254890,
a specific G(alpha)q/11 inhibitor, on thrombosis and neointima formation in mice.
Thromb Haemost. 2005 Jul;94(1):184-92. PubMed PMID: 16113802.
2: Taniguchi M, Suzumura K, Nagai K, Kawasaki T, Takasaki J, Sekiguchi M,
Moritani Y, Saito T, Hayashi K, Fujita S, Tsukamoto S, Suzuki K. YM-254890
analogues, novel cyclic depsipeptides with Galpha(q/11) inhibitory activity from
Chromobacterium sp. QS3666. Bioorg Med Chem. 2004 Jun 15;12(12):3125-33. PubMed
PMID: 15158780.
3: Kawasaki T, Taniguchi M, Moritani Y, Hayashi K, Saito T, Takasaki J, Nagai K,
Inagaki O, Shikama H. Antithrombotic and thrombolytic efficacy of YM-254890, a G
q/11 inhibitor, in a rat model of arterial thrombosis. Thromb Haemost. 2003
Sep;90(3):406-13. PubMed PMID: 12958608.
4: Taniguchi M, Nagai K, Arao N, Kawasaki T, Saito T, Moritani Y, Takasaki J,
Hayashi K, Fujita S, Suzuki K, Tsukamoto S. YM-254890, a novel platelet
aggregation inhibitor produced by Chromobacterium sp. QS3666. J Antibiot (Tokyo).
2003 Apr;56(4):358-63. PubMed PMID: 12817809.