For research use only. Not for therapeutic Use.
YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders[1].
YM-298198 hydrochloride shows a high affinity for mGluR1 with a Ki of 19 nM for rat mGluR1-NIH membranes[1].
YM-298198 hydrochloride inhibits glutamate-induced inositol phosphate production in mGluR1-NIH3T3 cells, with an IC50 of 16 nM[1].
YM-298198 hydrochloride shows neither agonistic nor antagonistic activity on mGluR2, 3, 4a, 6, or 7b up to 10 μM[1].
YM-298198 hydrochloride (30 mg/kg; p.o.) shows a significant analgesic effect in streptozotocin-induced hyperalgesic mice[1].
| Catalog Number | I010557 |
| CAS Number | 1216398-09-2 |
| Synonyms | 7-amino-N-cyclohexyl-N,1-dimethyl-[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide;hydrochloride |
| Molecular Formula | C18H23ClN4OS |
| Purity | ≥95% |
| InChI | InChI=1S/C18H22N4OS.ClH/c1-11-16(17(23)21(2)13-6-4-3-5-7-13)24-18-20-14-9-8-12(19)10-15(14)22(11)18;/h8-10,13H,3-7,19H2,1-2H3;1H |
| InChIKey | WYTJVUVCSUWZTH-UHFFFAOYSA-N |
| SMILES | CC1=C(SC2=NC3=C(N12)C=C(C=C3)N)C(=O)N(C)C4CCCCC4.Cl |
| Reference | [1]. Kohara, A, et al. Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and Noncompetitive Antagonist of Metabotropic Glu |
