YM155

• CAT Number: I004872
• CAS Number: 781661-94-7
• Molecular Formula: C₂₀H₁₉BrN₄O₃
• Molecular Weight: 443.29
• Purity: ≥95%
• Synonyms: 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
• Target: Autophagy
• Solubility: DMSO ≥85mg/mL Water ≥85mg/mL Ethanol ≥20mg/mL
• Storage: store at -20℃
• IC50: 0.54 nM
• InChI: InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
• InChIKey: QBIYUDDJPRGKNJ-UHFFFAOYSA-M
• SMILES: CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

YM155 (CAT: I004872) is a synthetic small molecule that has gained attention for its potential as an anticancer agent. It belongs to the class of survivin inhibitors and exhibits pharmacological activities against various types of cancer. YM155 works by targeting and suppressing the expression of survivin, a protein that promotes cell survival and is often overexpressed in cancer cells. By inhibiting survivin, YM155 induces apoptosis, inhibits cell proliferation, and sensitizes cancer cells to other anticancer treatments. It has shown promising results in preclinical and clinical studies, particularly in the treatment of advanced solid tumors and hematological malignancies.