For research use only. Not for therapeutic Use.
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones[1].
| Catalog Number | M135412 |
| CAS Number | 148869-05-0 |
| Synonyms | 4-[(4-bromophenyl)methyl-(1,2,4-triazol-4-yl)amino]benzonitrile |
| Molecular Formula | C16H12BrN5 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H12BrN5/c17-15-5-1-14(2-6-15)10-22(21-11-19-20-12-21)16-7-3-13(9-18)4-8-16/h1-8,11-12H,10H2 |
| InChIKey | GGPPBTSXFROGAE-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CN(C2=CC=C(C=C2)C#N)N3C=NN=C3)Br |
| Reference | [1]. M Kudoh, et al. The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511. J Steroid Biochem Mol Biol. 1995 Sep;54(5-6):265-71. |
