YN1

• CAT Number: I014762
• CAS Number: 75187-63-2
• Molecular Formula: C15H10O5
• Molecular Weight: 270.24
• Purity: ≥95%
• Synonyms: YN1; YN-1; YN 1;;7, 8-Dihydroxy-3-(4-hydroxyphenyl) chromen-4-one
• Target: PFKFB3 inhibitor
• Solubility: Soluble in DMSO
• InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H
• InChIKey: BMZFZTMWBCFKSS-UHFFFAOYSA-N
• SMILES: O=C1C(C2=CC=C(O)C=C2)=COC3=C1C=CC(O)=C3O

YN1 (Cat.No:I014762) is a potent inhibitor of PFKFB3 (6-Phosphfructo-2-kinase/fructose-2,6-bisphosphatase: IC₅₀ = 670 nM). PFKFB3 is over-expressed in many cancers and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YN1 inhibits glycolysis and proliferation in HeLa cells.

Reference

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