For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.<br>IC50 value:<br>Target:<br>In vitro:<br>In vivo: Yohimbine hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and motivation as indicated by increased latencies and intervals. Decreased copulatory activity was confirmed by decreased testosterone, luteinizing hormone (LH) and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes. Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats [1].<br></p>
| Catalog Number | I004458 |
| CAS Number | 65-19-0 |
| Synonyms | NIH 9689;NSC 19509;Yohimbe |
| Molecular Formula | C21H26N2O3 • HCl |
| Purity | ≥95% |
| Target | alpha 2-adrenergic receptor |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| InChIKey | PIPZGJSEDRMUAW-VJDCAHTMSA-N |
| Reference | <p style=/line-height:25px/> <br>[2]. Docherty JR. Yohimbine antagonises α1A- and α1D-adrenoceptor mediated components in addition to the α2A-adrenoceptor component to pressor responses in the pithed rat. Eur J Pharmacol. 2012 Mar 15;679(1-3):90-4. <br>[3]. Lahiri P, et al. Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. Blood Cells Mol Dis. 2009 Jul-Aug;43(1):105-10. </p> |
