For research use only. Not for therapeutic Use.
Yohimbine (Cat.No:I001776) is a naturally occurring alkaloid found in the bark of the yohimbe tree. It is known for its use as a traditional aphrodisiac and has been investigated for its potential in treating erectile dysfunction and anxiety-related disorders. However, caution is advised due to potential side effects and interactions with certain medications.
| Catalog Number | I001776 |
| CAS Number | 146-48-5 |
| Molecular Formula | C21H26N2O3 |
| Purity | ≥95% |
| Target | alpha 2-adrenergic receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 0.6 uM [1] |
| IUPAC Name | methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate |
| InChI | InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1 |
| InChIKey | BLGXFZZNTVWLAY-SCYLSFHTSA-N |
| SMILES | COC(=O)[C@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O |
| Reference | <p style=/line-height:25px/> <br>[2]. Blanchard RJ, et al. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice. Pharmacol Biochem Behav. 1993 Mar;44(3):673-681. <br>[3]. Fuller BB, et al. Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol. 2000 Feb;114(2):268-276. </p> |
