For research use only. Not for therapeutic Use.
The dual-functional compound YW2065 is a potent inhibitor of the Wnt/β-catenin signaling pathway (IC50 value of 2.3 nM) and an AMPK activator. YW2065 may achieve its dual activities through the mechanism of Axin-1 stabilization. YW2065 demonstrated favorable PK properties and suppressed tumor growth in a xenograft mouse model.
KEYWORDS: YW2065 | supplier | Wnt/β-catenin inhibitor/AMPK activator | YW-2065 | YW 2065 | CAS [2131223-85-1] | Wnt proteins | Wnt | Inhibitor | Proteins | Colorectal cancer | CRC
| Catalog Number | I038631 |
| CAS Number | 2131223-85-1 |
| Molecular Formula | C20H15BrN4O |
| Purity | ≥95% |
| IUPAC Name | 1-(2-bromophenyl)-5-methyl-N-quinolin-2-ylpyrazole-4-carboxamide |
| InChI | InChI=1S/C20H15BrN4O/c1-13-15(12-22-25(13)18-9-5-3-7-16(18)21)20(26)24-19-11-10-14-6-2-4-8-17(14)23-19/h2-12H,1H3,(H,23,24,26) |
| SMILES | CC1=C(C=NN1C2=CC=CC=C2Br)C(=O)NC3=NC4=CC=CC=C4C=C3 |
| Reference | W Yang at al. Pyrazole-4-Carboxamide (YW2065): A Therapeutic Candidate for Colorectal Cancer via Dual Activities of Wnt/β-Catenin Signaling Inhibition and AMP-Activated Protein Kinase (AMPK) Activation. J Med Chem. 2019 Dec 26;62(24):11151-11164. |
