YYA-021

• CAT Number: I001704
• CAS Number: 144217-65-2
• Molecular Formula: C18H27N3O2
• Molecular Weight: 317.40
• Purity: ≥95%
• Target: HIV
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 8.4 μM
• IUPAC Name: N'-(4-methylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)oxamide
• InChI: InChI=1S/C18H27N3O2/c1-12-6-8-13(9-7-12)19-15(22)16(23)20-14-10-17(2,3)21-18(4,5)11-14/h6-9,14,21H,10-11H2,1-5H3,(H,19,22)(H,20,23)
• InChIKey: AYAGJQPDCPRMNG-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)NC(=O)C(=O)NC2CC(NC(C2)(C)C)(C)C

YYA-021（Cat No.:I001704）is a high-purity small-molecule compound widely used in cancer and pharmaceutical research. As a potent inhibitor of the Wnt/β-catenin signaling pathway, it disrupts a key pathway involved in cell proliferation, migration, and tumor progression. YYA-021 is instrumental in studying the mechanisms of cancer development, particularly in Wnt-driven malignancies, and exploring therapeutic strategies targeting this pathway. Its specificity and robust activity make it a valuable tool for preclinical studies focused on drug discovery and the development of innovative treatments for cancers with aberrant Wnt signaling.

Reference

[1]. Mizuguchi T, et al. A minimally cytotoxic CD4 mimic as an HIV entry inhibitor. Bioorg Med Chem Lett. 2016 Jan 15;26(2):397-400.

[2]. Hashimoto C, et al. A CD4 mimic as an HIV entry inhibitor: pharmacokinetics. Bioorg Med Chem. 2013 Dec 15;21(24):7884-9.