YYA-021

• CAT Number: I001704
• CAS Number: 144217-65-2
• Molecular Formula: C18H27N3O2
• Molecular Weight: 317.4
• Purity: ≥95%
• Target: gp120/CD4
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 8.4 μM
• InChI: InChI=1S/C18H27N3O2/c1-12-6-8-13(9-7-12)19-15(22)16(23)20-14-10-17(2,3)21-18(4,5)11-14/h6-9,14,21H,10-11H2,1-5H3,(H,19,22)(H,20,23)
• InChIKey: AYAGJQPDCPRMNG-UHFFFAOYSA-N
• SMILES: CC1(C)CC(NC(C(NC2=CC=C(C)C=C2)=O)=O)CC(C)(C)N1

YYA-021 (Cat.No:I001704) is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV activity and low cytotoxicity. YYA-021 is broadly distributed in tissues, probably as a result of its hydrophobicity. The plasma concentrations of YYA-021 in both species remained at micromolar levels for several hours post-injection.

Reference

[1]. Mizuguchi T, et al. A minimally cytotoxic CD4 mimic as an HIV entry inhibitor. Bioorg Med Chem Lett. 2016 Jan 15;26(2):397-400.

[2]. Hashimoto C, et al. A CD4 mimic as an HIV entry inhibitor: pharmacokinetics. Bioorg Med Chem. 2013 Dec 15;21(24):7884-9.