For research use only. Not for therapeutic Use.
Cells that are rapidly proliferating or hypoxic emphasize glycolysis over oxidative phosphorylation to meet energy needs. During glycolysis, fructose 6-phosphate (F6P) is phosphorylated by 6-phosphofructo-2-kinases (PFKs) to generate fructose 2,6-bisphosphate. As PFK family members also mediate the reverse reaction as fructose 2,6-bisphosphatases, these enzymes are known as PFKFB family members. Notably, PFKFB3 is overexpressed in a wide variety of cancer cell lines. YZ9 is a potent inhibitor of PFKFB3, with an IC<sub>50</sub> value of 183 nM <em>in vitro</em>. It avidly competes with F6P at PFKFB3 (K<sub>i</sub> = 94 nM). YZ9 is also cell permeable, inhibiting the growth of HeLa cells with a GI<sub>50</sub> value of 2.7 µM.
| Catalog Number | R063926 |
| CAS Number | 6093-71-6 |
| Synonyms | 7-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic Acid Ethyl Ester;?3-Carbethoxy-7-hydroxycoumarin; 3-Carboethoxy-7-hydroxycoumarin; 3-Carboxy-7-hydroxycoumarin Ethyl Ester; 7-Hydroxy-2-oxo-2H-1-benzopyran-3-carboxylic Acid Ethyl Ester; 7-Hydroxy-3-(carbo |
| Molecular Formula | C12H10O5 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | ethyl 7-hydroxy-2-oxochromene-3-carboxylate |
| InChI | InChI=1S/C12H10O5/c1-2-16-11(14)9-5-7-3-4-8(13)6-10(7)17-12(9)15/h3-6,13H,2H2,1H3 |
| InChIKey | IETDBZQIWIJQJG-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CC2=C(C=C(C=C2)O)OC1=O |
