Z-321

• CAT Number: I020422
• CAS Number: 130849-58-0
• Molecular Formula: C19H24N2O2S
• Molecular Weight: 344.47
• Purity: ≥95%
• Synonyms: 2-(2,3-dihydro-1H-inden-2-yl)-1-[(4R)-4-(pyrrolidine-1-carbonyl)-1,3-thiazolidin-3-yl]ethanone
• InChI: InChI=1S/C19H24N2O2S/c22-18(11-14-9-15-5-1-2-6-16(15)10-14)21-13-24-12-17(21)19(23)20-7-3-4-8-20/h1-2,5-6,14,17H,3-4,7-13H2/t17-/m0/s1
• InChIKey: GDOVFSONSLOIAK-KRWDZBQOSA-N
• SMILES: C1CCN(C1)C(=O)C2CSCN2C(=O)CC3CC4=CC=CC=C4C3

Z-321 is a prolylendopeptidase (PEP) inhibitor.
Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity[1].

Reference

[1]. Oosuka I, et al. Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats. Jpn J Pharmacol. 2000 May;83(1):82-5.
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