Z-DEVD-FMK

• CAT Number: I002617
• CAS Number: 210344-95-9
• Molecular Formula: C30H41FN4O12
• Molecular Weight: 668.7
• Purity: ≥95%
• Synonyms: methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
• Target: Caspase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: GBJVAVGBSGRRKN-JYEBCORGSA-N

Z-DEVD-FMK (CAT: I002617) is a synthetic peptide-based compound that acts as an inhibitor of caspase-3, a key enzyme involved in the process of apoptosis (programmed cell death). It belongs to the class of peptide-based caspase inhibitors known as FMKs (fluoromethylketones). Z-DEVD-FMK specifically targets the active site of caspase-3, irreversibly inhibiting its activity and preventing the activation of downstream apoptotic pathways. This compound is commonly used in laboratory research to study the role of caspase-3 in cellular processes, apoptosis-related diseases, and to explore potential therapeutic interventions targeting apoptosis.

Reference

[1]. Rickers A, et al. Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL60 Burkitt lymphoma cells. Eur J Immunol. 1998, (1), 296-304.
[2]. Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424.
[3]. Wang J, et al. Involvement of caspase 3- and 8-like proteases in ceramide-induced apoptosis of cardiomyocytes. J Card Fail. 2000, 6(3), 243-249.
[4]. Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson/’s disease models. Free Radic Biol Med. 2006, 41(10), 1578-1589.