For research use only. Not for therapeutic Use.
Z-DEVD-FMK (Cat No.:I002617) is a synthetic peptide-based compound that acts as an inhibitor of caspase-3, a key enzyme involved in the process of apoptosis (programmed cell death). It belongs to the class of peptide-based caspase inhibitors known as FMKs (fluoromethylketones). Z-DEVD-FMK specifically targets the active site of caspase-3, irreversibly inhibiting its activity and preventing the activation of downstream apoptotic pathways. This compound is commonly used in laboratory research to study the role of caspase-3 in cellular processes, apoptosis-related diseases, and to explore potential therapeutic interventions targeting apoptosis.
| Catalog Number | I002617 |
| CAS Number | 210344-95-9 |
| Synonyms | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate |
| Molecular Formula | C30H41FN4O12 |
| Purity | ≥95% |
| Target | Caspase |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate |
| InChI | InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1 |
| InChIKey | GBJVAVGBSGRRKN-JYEBCORGSA-N |
| SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
| Reference | <p style=/line-height:25px/> |
