Z-Guggulsterone

• CAT Number: R042632
• CAS Number: 39025-23-5
• Molecular Formula: C21H28O2
• Molecular Weight: 312.45
• Purity: ≥95%
• Synonyms: (17Z)-Pregna-4,17(20)-diene-3,16-dione; ?(17Z)-Guggulsterone; 4,17(20)-cis-Pregnadiene-3,6-dione; cis-Guggulsterone
• Target: Protein Tyrosine Kinase/RTK
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at 2-8°C
• IUPAC Name: (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
• InChI: InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
• InChIKey: WDXRGPWQVHZTQJ-OSJVMJFVSA-N
• SMILES: CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Z-guggulsterone（Cat No.:R042632） is a bioactive compound found in Commiphora mukul, an Indian Ayurvedic medicinal plant. It demonstrates significant anti-prostate cancer effects by inducing apoptosis (programmed cell death) in human prostate cancer cells. Additionally, Z-guggulsterone inhibits angiogenesis, the formation of new blood vessels, by targeting the VEGF-VEGF-R2-Akt signaling axis. By disrupting this pathway, it hinders the growth and spread of cancer cells and exhibits potential as a therapeutic agent for prostate cancer treatment.