Z-IETD-FMK

• CAT Number: I011539
• CAS Number: 210344-98-2
• Molecular Formula: C30H43FN4O11
• Molecular Weight: 654.68
• Purity: ≥95%
• Synonyms: methyl 5-[[1-[(5-fluoro-1-methoxy-1,4-dioxopentan-3-yl)amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate
• Target: Caspase
• Solubility: >32.7mg/mL in DMSO
• Storage: Store at -20 C
• IUPAC Name: methyl (4S)-5-[[(2S,3R)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[(2S,3S)-3-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate
• InChI: InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)/t17-,18+,20-,21-,25-,26-/m0/s1
• InChIKey: PHLCQASLWHYEMX-DEKIMQJDSA-N
• SMILES: CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

Z-IETD-FMK (Cat No.:I011539) is a caspase inhibitor commonly used in laboratory research. It belongs to the class of peptide-based inhibitors that target caspases, which are enzymes involved in programmed cell death (apoptosis). Specifically, Z-IETD-FMK is a selective inhibitor of caspase-8, which plays a crucial role in the extrinsic apoptotic pathway. By inhibiting caspase-8, Z-IETD-FMK prevents its activation and subsequent downstream apoptotic signaling. This compound is often employed to study the involvement of caspase-8 in cellular processes and to explore potential therapeutic strategies targeting apoptotic pathways.