(Z)-JQ1-TCO

• CAT Number: I040046
• Molecular Formula: C31H37ClN6O3S
• Molecular Weight: 609.18
• Purity: ≥95%
• Synonyms: [(4Z)-cyclooct-4-en-1-yl] N-[3-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]propyl]carbamate
• InChI: InChI=1S/C31H37ClN6O3S/c1-19-20(2)42-30-27(19)28(22-12-14-23(32)15-13-22)35-25(29-37-36-21(3)38(29)30)18-26(39)33-16-9-17-34-31(40)41-24-10-7-5-4-6-8-11-24/h4-5,12-15,24-25H,6-11,16-18H2,1-3H3,(H,33,39)(H,34,40)/b5-4-/t24?,25-/m0/s1
• InChIKey: CYIPOINYTLBSLB-SBSQNJSVSA-N
• SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCCNC(=O)OC4CCCC=CCC4)C5=CC=C(C=C5)Cl)C

(Z)-JQ1-TCO (Cat No.: I040046) is a modified derivative of JQ1, a potent BET (bromodomain and extra-terminal) inhibitor, designed for bioorthogonal chemistry applications. It retains JQ1’s ability to disrupt BRD4-mediated transcription, making it valuable in cancer and epigenetic research. The trans-cyclooctene (TCO) modification enables click chemistry applications for targeted drug delivery and imaging studies. (Z)-JQ1-TCO is widely used in in vitro and in vivo research to study chromatin regulation, transcriptional control, and therapeutic strategies for cancer and inflammatory diseases.

Reference

[1]. Hu Z, et al. Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic. Chembiochem. 2022 Jan 19;23(2):e202100270.
[Content Brief]

[2]. Tyler DS, et al. Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science. 2017 Jun 30;356(6345):1397-1401.
[Content Brief]