Z-LEHD-FMK

• CAT Number: I011540
• CAS Number: 210345-04-3
• Molecular Formula: C32H43FN6O10
• Molecular Weight: 690.72
• Purity: ≥95%
• Synonyms: methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate
• Target: Caspase
• Solubility: Soluble in DMSO
• Storage: Store at -20 C
• InChI: InChI=1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)/t22-,23-,24-,25-/m0/s1
• InChIKey: YXRKBEPGVHOXSV-QORCZRPOSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2

Z-LEHD-FMK (Cat No.:I011540) is a cell-permeable and irreversible inhibitor of caspase-9, an enzyme involved in programmed cell death or apoptosis. Z-LEHD-FMK works by irreversibly binding to the active site of caspase-9, preventing it from carrying out its normal cellular functions. The inhibition of caspase-9 activity by Z-LEHD-FMK has been shown to prevent apoptosis and promote cell survival in various experimental models of injury and disease, such as ischemic stroke and neurodegenerative disorders. Z-LEHD-FMK has been used as a tool compound to study the role of caspase-9 in various cellular processes and as a potential therapeutic agent for the treatment of conditions characterized by excessive apoptosis, such as neurodegenerative diseases and ischemic injury.