Z-Leu-Leu-Glu-AMC

• CAT Number: R026079
• CAS Number: 348086-66-8
• Molecular Formula: C35H44N4O9
• Molecular Weight: 664.75
• Purity: ≥95%
• Synonyms: (4S)-4-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]-5-[(4-methyl-2-oxochromen-7-yl)amino]-5-oxopentanoic acid
• InChI: InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
• InChIKey: FOYHOBVZPWIGJM-KCHLEUMXSA-N
• SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC3=CC=CC=C3

Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome[1]

Reference

[1]. McNaught KS, et al. Proteasomal function is impaired in substantia nigra in Parkinson’s disease. Neurosci Lett. 2001 Jan 19;297(3):191-4.
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