For research use only. Not for therapeutic Use.
Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1].
Z-LEVD-FMK (2 ng/mL, 30 min) blocks IL-1β-induced IL-8 production in hRPE cells[1].
Z-LEVD-FMK (2 μM) inhibits caspase-3 activity in hRPE cells[1].
Z-LEVD-FMK (20 μM, 96 h) completely blocks E2-induced PARP cleavage in 5C cells[2].
Z-LEVD-FMK (20 μM, 96 h) reverses E2-inhibited growth and prevents morphologic alterations associated with apoptosis in 5C cells[2].
| Catalog Number | I042499 |
| CAS Number | 1135688-25-3 |
| Synonyms | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-oxopentanoate |
| Molecular Formula | C31H45FN4O10 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H45FN4O10/c1-18(2)14-23(35-31(43)46-17-20-10-8-7-9-11-20)29(41)33-21(12-13-25(38)44-5)28(40)36-27(19(3)4)30(42)34-22(24(37)16-32)15-26(39)45-6/h7-11,18-19,21-23,27H,12-17H2,1-6H3,(H,33,41)(H,34,42)(H,35,43)(H,36,40)/t21-,22-,23-,27-/m0/s1 |
| InChIKey | WGJLXPZGHLANRB-FAWUNYRSSA-N |
| SMILES | CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| Reference | [1]. Bian ZM, et al. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009 Dec;50(12):6006-14. [2]. Ariazi EA, et al. Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18879-86. |
