(Z)-Mutagenic Impurity of Tenofovir Disoproxil

• CAT Number: I013733
• CAS Number: 1464851-21-5
• Molecular Formula: C₈H₉N₅
• Molecular Weight: 175.19
• Purity: ≥95%
• Target: HIV
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 9-[(Z)-prop-1-enyl]purin-6-amine
• InChI: InChI=1S/C8H9N5/c1-2-3-13-5-12-6-7(9)10-4-11-8(6)13/h2-5H,1H3,(H2,9,10,11)/b3-2-
• InChIKey: ACWCANXGLNLMJB-IHWYPQMZSA-N
• SMILES: C/C=C\N1C=NC2=C(N=CN=C21)N

(Z)-Mutagenic Impurity of Tenofovir Disoproxil（Cat No.:I013733）is a potential byproduct formed during the synthesis of Tenofovir Disoproxil, a nucleotide analog prodrug used in the treatment of HIV and hepatitis B. This impurity is of significant concern due to its potential mutagenic properties, necessitating stringent analytical and quality control measures in pharmaceutical manufacturing. Research on this impurity focuses on its formation pathways, characterization, and impact on drug safety. Its study is critical for ensuring regulatory compliance, minimizing risks, and enhancing the safety profile of Tenofovir-based therapies.