For research use only, not for therapeutic use.
Z-<wbr></wbr>VAD(OH)-<wbr></wbr>FMK is an irreversible tripeptide inhibitor of all caspases. This non-<wbr></wbr>methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-<wbr></wbr>VAD(OMe)-<wbr></wbr>FMK (Item No. <span class=/itemid/>14463</span>), this compound does not require pretreatment with esterases prior to <em>in vitro</em> use.
| Catalog Number | M132012 |
| CAS Number | 161401-82-7 |
| Synonyms | Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone |
| Molecular Formula | C21H28FN3O7 |
| Purity | ≥95% |
| Storage | -20°C |
| IUPAC Name | (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoic acid |
| InChI | InChI=1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1 |
| InChIKey | SUUHZYLYARUNIA-YEWWUXTCSA-N |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
