For research use only. Not for therapeutic Use.
Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively[1].
Z433927330 inhibits glycerol permeability, with an IC50 of ~0.6 µM[1].
| Catalog Number | I019157 |
| CAS Number | 1005883-72-6 |
| Synonyms | ethyl 4-[(4-pyrazol-1-ylphenyl)methylcarbamoylamino]benzoate |
| Molecular Formula | C20H20N4O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H20N4O3/c1-2-27-19(25)16-6-8-17(9-7-16)23-20(26)21-14-15-4-10-18(11-5-15)24-13-3-12-22-24/h3-13H,2,14H2,1H3,(H2,21,23,26) |
| InChIKey | KQUKHINHCUELQL-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=CC=C(C=C1)NC(=O)NCC2=CC=C(C=C2)N3C=CC=N3 |
| Reference | [1]. Z433927330, et al. Identification and characterization of potent and selective aquaporin-3 and aquaporin-7 inhibitors. J Biol Chem. 2019 May 3;294(18):7377-7387. |
