For research use only. Not for therapeutic Use.
Z4P is a BBB-permeable IRE1 inhibitor (IC50: 1.11 μM). Z4P inhibits Glioblastoma cell growth. Z4P prevents glioblastoma relapse when administered together with Temozolomide (HY-17364)[1].
| Catalog Number | I041070 |
| CAS Number | 2361760-87-2 |
| Synonyms | 1-(2,5-dimethylphenyl)-3-[4-(4-hydroxyphenyl)butan-2-yl]urea |
| Molecular Formula | C19H24N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H24N2O2/c1-13-4-5-14(2)18(12-13)21-19(23)20-15(3)6-7-16-8-10-17(22)11-9-16/h4-5,8-12,15,22H,6-7H2,1-3H3,(H2,20,21,23) |
| InChIKey | SWCGKGWNEOWHGC-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1)C)NC(=O)NC(C)CCC2=CC=C(C=C2)O |
| Reference | [1]. Pelizzari-Raymundo D, et al. A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment. iScience. 2023 Apr 24;26(5):106687. |
