For research use only. Not for therapeutic Use.
Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC)[1].
| Catalog Number | I040057 |
| CAS Number | 1016340-64-9 |
| Synonyms | 2-[[2-(4-methylanilino)quinazolin-4-yl]amino]ethanol |
| Molecular Formula | C17H18N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C17H18N4O/c1-12-6-8-13(9-7-12)19-17-20-15-5-3-2-4-14(15)16(21-17)18-10-11-22/h2-9,22H,10-11H2,1H3,(H2,18,19,20,21) |
| InChIKey | GJTXWNCGKNQIFN-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)NC2=NC3=CC=CC=C3C(=N2)NCCO |
| Reference | [1]. He Y, et al. Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo. Eur J Med Chem. 2024 Mar 5;267:116209. |
