ZARAGOZIC ACID A

• CAT Number: M133764
• CAS Number: 142561-96-4
• Molecular Formula: C35H46O14
• Molecular Weight: 690.74
• Purity: ≥95%
• Synonyms: (1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-acetoxy-5-methyl-3-methylene-6-phenylhexyl)-6-(((4S,6S,E)-4,6-dimethyloct-2-enoyl)oxy)-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
• Target: Disease Research Fields
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1S,3S,4S,5R,6R,7R)-1-[(4S,5R)-4-acetyloxy-5-methyl-3-methylidene-6-phenylhexyl]-6-[(E,4S,6S)-4,6-dimethyloct-2-enoyl]oxy-4,7-dihydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
• InChI: InChI=1S/C35H46O14/c1-7-19(2)17-20(3)13-14-25(37)47-28-27(38)33(48-29(30(39)40)34(45,31(41)42)35(28,49-33)32(43)44)16-15-21(4)26(46-23(6)36)22(5)18-24-11-9-8-10-12-24/h8-14,19-20,22,26-29,38,45H,4,7,15-18H2,1-3,5-6H3,(H,39,40)(H,41,42)(H,43,44)/b14-13+/t19-,20+,22+,26+,27+,28+,29+,33-,34+,35-/m0/s1
• InChIKey: DFKDOZMCHOGOBR-NCSQYGPNSA-N
• SMILES: CCC(C)CC(C)C=CC(=O)OC1C(C2(OC(C(C1(O2)C(=O)O)(C(=O)O)O)C(=O)O)CCC(=C)C(C(C)CC3=CC=CC=C3)OC(=O)C)O

Zaragozic acid A(CAT: M133764), also known as Squalestatin 1, is a potent natural inhibitor of squalene synthase, an enzyme involved in cholesterol biosynthesis. It was originally isolated from fungi and has attracted attention for its ability to block the mevalonate pathway, which is crucial in cholesterol and isoprenoid biosynthesis. Due to its inhibitory effects on squalene synthase, zaragozic acid A has been studied as a potential therapeutic agent for hypercholesterolemia and cardiovascular diseases. Additionally, its role in inhibiting other pathways related to cell growth and metabolism has made it a subject of interest in cancer research and related metabolic disorders.