For research use only. Not for therapeutic Use.
Zardaverine (Cat.No:I000141) is a chemical compound with pharmacological significance. It is known for its potential as a selective phosphodiesterase inhibitor, which could have therapeutic applications in treating certain medical conditions. Researchers are exploring its properties to better understand its effects and potential benefits in the field of medicine.
| Catalog Number | I000141 |
| CAS Number | 101975-10-4 |
| Synonyms | 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one |
| Molecular Formula | C12H10F2N2O3 |
| Purity | ≥95% |
| Target | PDE |
| Solubility | DMSO: ≥ 28 mg/mL |
| Storage | Store at -20°C |
| IC50 | 0.5 uM (PDE3); 0.8 uM (PDE4) |
| Reference | </br>1:Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient. Cartledge DM, Robbins KM, Drake KM, Sternberg R, Stabley DL, Gripp KW, Kolb EA, Sol-Church K, Napper AD.Front Oncol. 2017 Apr 3;7:42. doi: 10.3389/fonc.2017.00042. eCollection 2017. PMID: 28421158 Free PMC Article</br>2:Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition. Sun L, Quan H, Xie C, Wang L, Hu Y, Lou L.PLoS One. 2014 Mar 5;9(3):e90627. doi: 10.1371/journal.pone.0090627. eCollection 2014. PMID: 24598942 Free PMC Article</br>3:Zardaverine and aerosolised iloprost in a model of acute respiratory failure. Schermuly RT, Leuchte H, Ghofrani HA, Weissmann N, Rose F, Kohstall M, Olschewski H, Schudt C, Grimminger F, Seeger W, Walmrath D.Eur Respir J. 2003 Aug;22(2):342-7. PMID: 12952271 Free Article</br>4:Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction. Ukena D, Rentz K, Reiber C, Sybrecht GW.Respir Med. 1995 Jul;89(6):441-4. PMID: 7644776 Free Article</br>5:Comparative investigation of the effects of zardaverine and theophylline on pulmonary function in rats. Hoymann HG, Heinrich U, Beume R, Kilian U.Exp Lung Res. 1994 May-Jun;20(3):235-50. PMID: 7925141 </br>6:The effect of zardaverine, an inhibitor of phosphodiesterase isoenzymes III and IV, on endotoxin-induced airway changes in rats. Kips JC, Joos GF, Peleman RA, Pauwels RA.Clin Exp Allergy. 1993 Jun;23(6):518-23. PMID: 8369979 </br>7:The specific type III and IV phosphodiesterase inhibitor zardaverine suppresses formation of tumor necrosis factor by macrophages. Schade FU, Schudt C.Eur J Pharmacol. 1993 Jan 5;230(1):9-14. PMID: 8381357 </br>8:Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma. Brunnée T, Engelstätter R, Steinijans VW, Kunkel G.Eur Respir J. 1992 Sep;5(8):982-5. PMID: 1426207 </br>9:Sensitive determination of the phosphodiesterase III/IV inhibitor zardaverine in human serum by direct sample injection, automated precolumn clean-up and high-performance liquid chromatography. Huber R, Schildnitz U.J Chromatogr. 1991 Aug 16;553(1-2):65-70. PMID: 1787170 </br>10:Zardaverine as a selective inhibitor of phosphodiesterase isozymes. Schudt C, Winder S, Müller B, Ukena D.Biochem Pharmacol. 1991 Jun 21;42(1):153-62. PMID: 1648920 |
