Zatebradine

• CAT Number: I005110
• CAS Number: 85175-67-3
• Molecular Formula: C26H36N2O5
• Molecular Weight: 456.57
• Purity: ≥95%
• Target: HCN Channel
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 10 uM(92% 92% inhibition of the hHCN1) [1]

Zatebradine(CAT: I005110) is a selective inhibitor of the If (funny current) in cardiac cells. It primarily acts as a sinus node blocker, slowing down the heart rate and reducing its contractility. Zatebradine is commonly used in the management of angina pectoris and certain cardiac arrhythmias, such as supraventricular tachycardia. By inhibiting the If current, it helps to regulate the electrical activity of the heart and decrease myocardial oxygen consumption. Zatebradine is considered a selective and relatively well-tolerated agent for controlling heart rate in specific cardiovascular conditions.

Reference

[1]. Gill CH, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21.

[2]. Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71.

[3]. Matt L, et al. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci. 2011 Jan;68(1):125-37.