Zaurategrast

• CAT Number: I003597
• CAS Number: 455264-31-0
• Molecular Formula: C26H25BrN4O3
• Molecular Weight: 521.42
• Purity: ≥95%
• Synonyms: (2S)-2-[(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino]-3-[4-(2,7-naphthyridin-1-ylamino)phenyl]propanoic acid
• Target: Integrin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C26H25BrN4O3/c27-21-22(26(23(21)32)10-2-1-3-11-26)31-20(25(33)34)14-16-4-6-18(7-5-16)30-24-19-15-28-12-8-17(19)9-13-29-24/h4-9,12-13,15,20,31H,1-3,10-11,14H2,(H,29,30)(H,33,34)/t20-/m0/s1
• InChIKey: KYHVWHYLKOHLKA-FQEVSTJZSA-N
• SMILES: O=C(O)[C@@H](NC1=C(Br)C(C12CCCCC2)=O)CC3=CC=C(NC4=NC=CC5=C4C=NC=C5)C=C3

Zaurategrast (Cat.No:I003597) is a promising pharmaceutical compound under study for its potential anti-inflammatory properties. It belongs to the family of integrin antagonists, targeting a key protein involved in immune response regulation. Researchers are investigating its potential in treating inflammatory disorders, offering hope for improved therapeutic options in the future.

Reference

[1]. Wolf C, et al. Pharmacodynamic consequences of administration of VLA-4 antagonist CDP323 to multiple sclerosis subjects: a randomized, double-blind phase 1/2 study. PLoS One. 2013;8(3):e58438.

[2]. Chanteux H, et al. In Vitro Hydrolysis and Transesterification of CDP323, an α4β1/α4β7 Integrin Antagonist Ester Prodrug. Drug Metab Dispos. 2014 Jan;42(1):153-61.