For research use only. Not for therapeutic Use.
ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain[1].
| Catalog Number | I010139 |
| CAS Number | 1998197-39-9 |
| Synonyms | 6-methyl-3-(2-nitro-1-thiophen-2-ylethyl)-2-phenyl-1H-indole |
| Molecular Formula | C21H18N2O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3 |
| InChIKey | RJSPNRDBWHHFMH-UHFFFAOYSA-N |
| SMILES | CC1=CC2=C(C=C1)C(=C(N2)C3=CC=CC=C3)C(C[N+](=O)[O-])C4=CC=CS4 |
| Reference | [1]. Ignatowska-Jankowska BM, et al. A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015;40(13):2948-2959. |
