For research use only. Not for therapeutic Use.
ZEN-2759 is a potent BET (Bromodomain and Extra-Terminal Domain) inhibitor, with IC50 values of 0.23, 0.08 and 0.28 μM for BRD4(BD1), BRD4(BD2), and BRD4(BD1BD2), respectively[1].
| Catalog Number | I038679 |
| CAS Number | 1616400-50-0 |
| Synonyms | 1-benzyl-5-(3,5-dimethyl-1,2-oxazol-4-yl)pyridin-2-one |
| Molecular Formula | C17H16N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H16N2O2/c1-12-17(13(2)21-18-12)15-8-9-16(20)19(11-15)10-14-6-4-3-5-7-14/h3-9,11H,10H2,1-2H3 |
| InChIKey | CIJOVPIWGFQZFF-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NO1)C)C2=CN(C(=O)C=C2)CC3=CC=CC=C3 |
| Reference | [1]. Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211. |
