ZEN-3411

• CAT Number: I038680
• CAS Number: 1952264-36-6
• Molecular Formula: C21H20N4O2
• Molecular Weight: 360.42
• Purity: 98%
• Synonyms: ZEN-3411; ZEN3411; ZEN 3411
• Target: Epigenetic Reader Domain
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 6-(3,5-dimethylisoxazol-4-yl)-1-(4-(oxiran-2-yl)benzyl)-1H-benzo[d]imidazol-4-amine
• InChI: InChI=1S/C21H20N4O2/c1-12-20(13(2)27-24-12)16-7-17(22)21-18(8-16)25(11-23-21)9-14-3-5-15(6-4-14)19-10-26-19/h3-8,11,19H,9-10,22H2,1-2H3
• InChIKey: XINQCOMOQIYWTG-UHFFFAOYSA-N
• SMILES: NC1=CC(C2=C(C)ON=C2C)=CC3=C1N=CN3CC4=CC=C(C5OC5)C=C4

ZEN-3411(CAT: I038680) is a potent and selective BET inhibitor that targets the BRD4 protein, specifically its BD1, BD2, and BD1BD2 domains. By blocking BRD4’s interaction with acetylated histones, ZEN-3411 disrupts the transcription of genes involved in cancer progression and inflammation. Additionally, ZEN-3411 can be incorporated into PROTACs (Proteolysis Targeting Chimeras) to induce selective degradation of BRD4, enhancing its therapeutic efficacy. This dual mechanism makes ZEN-3411 a valuable tool in epigenetic and oncology research, offering significant potential for developing targeted therapies against BET protein-driven cancers and other diseases.