For research use only. Not for therapeutic Use.
ZEN-3411 is a BET inhibitor for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3411 can be used to form PROTACs to induce degradation of BRD4.
| Catalog Number | I038680 |
| CAS Number | 1952264-36-6 |
| Synonyms | ZEN-3411; ZEN3411; ZEN 3411 |
| Molecular Formula | C21H20N4O2 |
| Purity | 98% |
| Target | Epigenetic Reader Domain |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 6-(3,5-dimethylisoxazol-4-yl)-1-(4-(oxiran-2-yl)benzyl)-1H-benzo[d]imidazol-4-amine |
| InChI | InChI=1S/C21H20N4O2/c1-12-20(13(2)27-24-12)16-7-17(22)21-18(8-16)25(11-23-21)9-14-3-5-15(6-4-14)19-10-26-19/h3-8,11,19H,9-10,22H2,1-2H3 |
| InChIKey | XINQCOMOQIYWTG-UHFFFAOYSA-N |
| SMILES | NC1=CC(C2=C(C)ON=C2C)=CC3=C1N=CN3CC4=CC=C(C5OC5)C=C4 |
| Reference | 1: Kharenko OA, Patel RG, Brown SD, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018;61(18):8202-8211. doi:10.1021/acs.jmedchem.8b00666 |
