For research use only. Not for therapeutic Use.
Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger <em>Z. zerumbet</em>. It potently inhibits the activation of Epstein-<wbr></wbr>Barr virus by phorbol esters (IC<sub>50</sub> = 140 nM). Zerumbone inhibits Sonic hedgehog signaling and induces apoptosis in cancer cell lines. It has also been shown to have anti-<wbr></wbr>oxidant and anti-<wbr></wbr>inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.
| Catalog Number | R065041 |
| CAS Number | 471-05-6 |
| Synonyms | (2E,6E)-2,6,9,9-tetramethyl-2,6,10E-cycloundecatrien-1-one |
| Molecular Formula | C15H22O |
| Purity | ≥95% |
| Target | Anti-infection |
| Storage | -20°C |
| InChI | InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7- |
| InChIKey | GIHNTRQPEMKFKO-WHILTJODSA-N |
| SMILES | CC1(C)C/C=C(C)/CC/C=C(C)C(/C=C/1)=O |
| Reference | 1.Murakami, A.,Takahashi, M.,Jiwajinda, S., et al. Identification of zerumbone in Zingiber zerumbet smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Bioscience, Biotechnology, and Biochemistry 63(1 |
