For research use only. Not for therapeutic Use.
Zidovudine（Cat No.:A000294）, also known as AZT, is a nucleoside reverse transcriptase inhibitor (NRTI) widely used in HIV research. It acts by integrating into viral DNA, blocking reverse transcriptase activity, and inhibiting viral replication. Zidovudine has been instrumental in the development of antiretroviral therapies, providing insights into the treatment and management of HIV/AIDS. Its role extends to studying viral resistance mechanisms and combination therapy efficacy. As a well-characterized compound, Zidovudine is a critical tool in virology research, contributing to advancements in understanding retroviral infections and therapeutic approaches.
| Catalog Number | A000294 |
| CAS Number | 30516-87-1 |
| Synonyms | Azidothymidine; 3/’-Azido-3/’-deoxythymidine; 30516-87-1; Retrovir; AZT |
| Molecular Formula | C10H13N5O4 |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | >8.4mg/mL in DMSO |
| Storage | -20°C |
| IUPAC Name | 1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| InChI | InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1 |
| InChIKey | HBOMLICNUCNMMY-XLPZGREQSA-N |
| SMILES | CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-] |
| Reference | 1: Cook LB, Rowan AG, Demontis MA, Sagawe S, Gillet NA, Melamed A, Greiller C, 2: Pîrnău A, Mic M, Neamţu S, Floare CG, Bogdan M. Calorimetric and spectroscopic <br> <br> 5: Ramanathan R, Sivanesan K. Investigations on the Influence of Zidovudine in 6: Serrano-Villar S, Caruana G, Zlotnik A, Pérez-Molina JA, Moreno S. The effects 7: Joshy KS, Susan MA, Snigdha S, Nandakumar K, Laly AP, Sabu T. Encapsulation of 8: Bosire R, Farquhar C, Nduati R, Broliden K, Luchters S, Van de Perre P, De 9: Yan JK, Wang YY, Qiu WY, Wu JY. Construction and characterization of nanosized <br> |
