Zimeldine hydrochloride hydrate

• CAT Number: I038698
• CAS Number: 61129-30-4
• Molecular Formula: C16H21BrCl2N2O
• Molecular Weight: 408.16
• Purity: 98%
• Synonyms: H 102/09 hydrochloride monohydrate; Zimeldine hydrochloride hydrate; Zimeldine HCl hydrate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (Z)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-3-ylprop-2-en-1-amine;hydrate;dihydrochloride
• InChI: InChI=1S/C16H17BrN2.2ClH.H2O/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;;/h3-10,12H,11H2,1-2H3;2*1H;1H2/b16-9-
• InChIKey: WFUAVXYXJOQWAZ-GVKRCPFFSA-N
• SMILES: CN(C)C/C=C(/C1=CC=C(C=C1)Br)\C2=CN=CC=C2.O.Cl.Cl

Zimeldine hydrochloride hydrate（Cat No.:I038698）is a selective serotonin reuptake inhibitor (SSRI) that was initially developed as an antidepressant. It works by increasing serotonin levels in the brain, which can help alleviate symptoms of depression and anxiety. Although it showed promise in early clinical studies, Zimeldine was eventually withdrawn from the market due to safety concerns, particularly related to adverse effects on the cardiovascular system and potential for neurotoxicity. Research into its pharmacological profile continues, but it is no longer widely used as a therapeutic agent for treating depression.

Reference

1. Seppälä T, Linnoila M. Effects of zimeldine and other antidepressants on skilled performance: a comprehensive review. Acta Psychiatr Scand Suppl. 1983;308:135-40. doi: 10.1111/j.1600-0447.1983.tb11114.x. PMID: 6230887.