For research use only. Not for therapeutic Use.
ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC)[1].
ZINC00784494 (0.01-100 µM; 72 h) reduces cell proliferation and cell viability in SUM149 cells[1].
ZINC00784494 (1, 10 µM; 15 min, 1 h) reduces the p-Akt levels in SUM149 cells[1].
| Catalog Number | I042619 |
| CAS Number | 317328-17-9 |
| Synonyms | 3-[2-(3-acetylanilino)-1,3-thiazol-4-yl]chromen-2-one |
| Molecular Formula | C20H14N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H14N2O3S/c1-12(23)13-6-4-7-15(9-13)21-20-22-17(11-26-20)16-10-14-5-2-3-8-18(14)25-19(16)24/h2-11H,1H3,(H,21,22) |
| InChIKey | KUKVCIJGVUUCEV-UHFFFAOYSA-N |
| SMILES | CC(=O)C1=CC(=CC=C1)NC2=NC(=CS2)C3=CC4=CC=CC=C4OC3=O |
| Reference | [1]. Santiago-Sánchez GS, et al. Targeting Lipocalin-2 in Inflammatory Breast Cancer Cells with Small Interference RNA and Small Molecule Inhibitors. Int J Mol Sci. 2021 Aug 10;22(16):8581. |
