ZINC03129319

• CAT Number: I020079
• CAS Number: 1777807-64-3
• Molecular Formula: C₂₄H₁₄N₂O₆S₂
• Molecular Weight: 490.51
• Purity: ≥95%
• Target: Dengue virus
• Storage: Store at -20°C
• InChI: InChI=1S/C24H14N2O6S2/c27-17-11-5-1-2-6-12(11)18(28)23(17)25-15(9-33-23)22(32)26-16(21(25)31)10-34-24(26)19(29)13-7-3-4-8-14(13)20(24)30/h1-8,15-16H,9-10H2/t15-,16-/m1/s1
• InChIKey: GBYAWPJNMFAKDJ-HZPDHXFCSA-N
• SMILES: C1[C@@H]2C(=O)N3[C@H](CSC34C(=O)C5=CC=CC=C5C4=O)C(=O)N2C6(S1)C(=O)C7=CC=CC=C7C6=O

ZINC03129319（Cat No.:I020079）is a small-molecule inhibitor targeting the dengue virus (DENV) NS2B-NS3 protease, an enzyme crucial for viral replication. By binding to this protease, ZINC03129319 disrupts the virus’s ability to process its polyprotein, thereby hindering maturation and replication. In vitro studies have demonstrated its inhibitory constants (Ki) of 92 μM and 20 μM, indicating potential efficacy against DENV. As dengue fever remains a significant global health concern, ZINC03129319 offers promise as a therapeutic candidate, warranting further research to assess its effectiveness and safety in clinical settings.

Reference

[1]. Watowich, Stanley J, et al. SMALL-MOLECULE INHIBITORS OF DENGUE VIRUS PROTEASES. US20150141521A1.