Zinquin Ethyl Ester

• CAT Number: R000485
• CAS Number: 181530-09-6
• Molecular Formula: C21H22N2O5S
• Molecular Weight: 414.476
• Purity: ≥95%
• Synonyms: Ethyl [2-methyl-8-[[(4-methylphenyl)sulfonyl]amino]-6-quinolinyl]oxy Acetate
• Storage: -20°C
• IUPAC Name: ethyl 2-[2-methyl-8-[(4-methylphenyl)sulfonylamino]quinolin-6-yl]oxyacetate
• InChI: InChI=1S/C21H22N2O5S/c1-4-27-20(24)13-28-17-11-16-8-7-15(3)22-21(16)19(12-17)23-29(25,26)18-9-5-14(2)6-10-18/h5-12,23H,4,13H2,1-3H3
• InChIKey: KCASTCXJTDRDFT-UHFFFAOYSA-N
• SMILES: CCOC(=O)COC1=CC(=C2C(=C1)C=CC(=N2)C)NS(=O)(=O)C3=CC=C(C=C3)C

Zinquin ethyl ester is a cell-<wbr></wbr>permeable, quinolone-<wbr></wbr>based fluorescent probe used as a zinc indicator. In live cells, cytosolic esterases cleave the ethyl ester group preventing its efflux across the plasma membrane. This probe is UV-<wbr></wbr>excitable and emits in the blue region of the spectrum (excitation 368 nm, emission 490 nm). Zinquin ethyl ester has been used to monitor intracellular zinc fluxes associated with apoptosis.