For research use only. Not for therapeutic Use.
Ziprazidone is approved for the treatment of schizophrenia, and acute mania and mixed states associated with bipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate. The mechanism of action of ziprasidone, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug/’s efficacy in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. As with other drugs having efficacy in bipolar disorder, the mechanism of action of ziprasidone in bipolar disorder is unknown.
| Catalog Number | I010152 |
| CAS Number | 146939-27-7 (free base) |
| Synonyms | CP88059; CP-88059; CP 88059; CP-88,059; CP-88,059-01; CP88059 hydrochloride; Ziprasidone HCl, brand name: Geodon; Zeldox; Zipwell.;5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one |
| Molecular Formula | C21H21ClN4OS |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| Reference | </br>1:The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption. Sutton SC, Nause R, Gandelman K.AAPS J. 2017 Mar 20. doi: 10.1208/s12248-017-0065-9. [Epub ahead of print] PMID: 28321831 </br>2:Effects of aripiprazole, quetiapine and ziprasidone on plasma prolactin levels in individuals with first episode nonaffective psychosis: Analysis of a randomized open-label 1year study. Crespo-Facorro B, Ortiz-Garcia de la Foz V, Suarez-Pinilla P, Valdizan EM, Pérez-Iglesias R, Amado-Señaris JA, Teresa Garcia-Unzueta M, Labad J, Correll C, Ayesa-Arriola R.Schizophr Res. 2017 Feb 17. pii: S0920-9964(17)30059-2. doi: 10.1016/j.schres.2017.01.046. [Epub ahead of print] PMID: 28223031 </br>3:A neuroimaging study of emotion-cognition interaction in schizophrenia: the effect of ziprasidone treatment. Stip E, Cherbal A, Luck D, Zhornitsky S, Bentaleb LA, Lungu O.Psychopharmacology (Berl). 2017 Apr;234(7):1045-1058. doi: 10.1007/s00213-017-4533-9. Epub 2017 Feb 17. PMID: 28210783 </br>4:Intramuscular Ziprasidone Dosing for Acute Agitation in the Pediatric Emergency Department. Nguyen T, Stanton J, Foster R.J Pharm Pract. 2017 Jan 1:897190017692922. doi: 10.1177/0897190017692922. [Epub ahead of print] PMID: 28205446 </br>5:Development of a UPLC-MS/MS method for routine therapeutic drug monitoring of aripiprazole, amisulpride, olanzapine, paliperidone and ziprasidone with a discussion of their therapeutic reference ranges for Chinese patients. Wang ST, Li Y.Biomed Chromatogr. 2017 Jan 5. doi: 10.1002/bmc.3928. [Epub ahead of print] PMID: 28054367 </br>6:ISMP Adverse Drug Reactions: Chronic Marijuana Use Associated With Recurrent Diabetic Ketoacidosis Lamotrigine-Induced Cataplexy Trimethoprim-Sulfamethoxazole-Induced Hyponatremia Ziprasidone-Induced Sleepwalking and Sleep-Related Eating Metabolic Acidosis Associated With Acetaminophen. Mancano MA.Hosp Pharm. 2016 Nov;51(10):805-809. PMID: 27928184 </br>7:Kounis syndrome and ziprasidone. Hamera L, Khishfe BF.Am J Emerg Med. 2017 Mar;35(3):493-494. doi: 10.1016/j.ajem.2016.11.061. Epub 2016 Nov 30. PMID: 27919473 </br>8:Ziprasidone induces cytotoxicity and genotoxicity in human peripheral lymphocytes. Kefelioğlu H, Atlı Şekeroğlu Z, Coşguner G, Kontaş Yedier S, Şekeroğlu V.Drug Chem Toxicol. 2016 Nov 29:1-7. [Epub ahead of print] PMID: 27894189 </br>9:Ziprasidone-induced sub acute cutaneous lupus erythematosus. Codina MQ, Vila LC, Ninot GM, Redonnet MS.Lupus. 2017 Jun;26(7):785-786. doi: 10.1177/0961203316678676. Epub 2016 Nov 12. No abstract available. PMID: 27838681 </br>10:An assessor-blinded, randomized comparison of efficacy and tolerability of switching from olanzapine to ziprasidone and the combination of both in schizophrenia spectrum disorders. Wang HH, Cai M, Wang HN, Chen YC, Zhang RG, Wang Y, McAlonan GM, Bai YH, Wu WJ, Guo L, Zhang YH, Tan QR, Zhang ZJ.J Psychiatr Res. 2017 Feb;85:59-65. doi: 10.1016/j.jpsychires.2016.11.002. Epub 2016 Nov 4. PMID: 27837658 |
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