For research use only. Not for therapeutic Use.
(-)-ZK 216348（Cat No.:I041237）is a selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), which plays a key role in neurotransmission and synaptic plasticity. By inhibiting mGluR5, this compound can modulate glutamate signaling, potentially offering therapeutic benefits for various neurological and psychiatric conditions, including anxiety, depression, and neurodegenerative diseases like Parkinson’s and Alzheimer’s. (-)-ZK 216348 has been studied for its ability to reduce excitotoxicity and inflammatory responses in the central nervous system. It is being explored for its potential to treat disorders involving glutamate dysregulation and neuronal dysfunction.
| Synonyms | 4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide |
| Molecular Formula | C24H23F3N2O5 |
| Purity | ≥95% |
| IUPAC Name | 4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide |
| InChI | InChI=1S/C24H23F3N2O5/c1-13-17-11-15(7-8-16(17)20(30)34-29-13)28-21(31)23(32,24(25,26)27)12-22(2,3)18-6-4-5-14-9-10-33-19(14)18/h4-8,11,32H,9-10,12H2,1-3H3,(H,28,31) |
| InChIKey | VRZVKIJRJRBQJT-UHFFFAOYSA-N |
| SMILES | CC1=NOC(=O)C2=C1C=C(C=C2)NC(=O)C(CC(C)(C)C3=CC=CC4=C3OCC4)(C(F)(F)F)O |
