ZK 756326 dihydrochloride

• CAT Number: I010155
• CAS Number: 1780259-94-0
• Molecular Formula: C21H28N2O3.2HCl
• Molecular Weight: 429.38
• Purity: ≥95%
• IUPAC Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride
• InChI: InChI=1S/C21H28N2O3.2ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;;/h1-8,17,24H,9-16,18H2;2*1H
• SMILES: C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl

ZK 756326 dihydrochloride is a nonpeptide chemokine CCR8 receptor agonist (IC50 value of 1.8 μM). This compound may be useful in evaluating the physiological role of CCR8 in HIV infection, as well as in the general study of CCR8 biology without the constraints inherent to the use of protein agonists such as its natural ligand.
KEYWORDS: ZK 756326 dihydrochloride | supplier | CCR8 agonist | ZK756326 dihydrochloride | ZK-756326 dihydrochloride | CAS [1780259-94-0] | [874911-96-3] | Chemokine | Agonist | Receptors | HIV

Reference

CA Haskell et al. Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16.