For research use only. Not for therapeutic Use.
ZK-91296 is a GABA receptor agonist potentially for the treatment of anxiety. ZK 91296 can reduce anxiety in animals at doses well below those causing sedation. ZK 91296 may possess pharmacological selectivity for a particular type of BZ receptor interaction, perhaps including topographic as well as receptor subtype differentiation.
| Catalog Number | I010156 |
| CAS Number | 83910-34-3 |
| Synonyms | ZK-91296; ZK 91296; ZK91296.;ethyl 5-(benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylate |
| Molecular Formula | C23H22N2O4 |
| Purity | ≥95% |
| Target | GABA receptor agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | ethyl 4-(methoxymethyl)-5-phenylmethoxy-9H-pyrido[3,4-b]indole-3-carboxylate |
| InChI | InChI=1S/C23H22N2O4/c1-3-28-23(26)22-16(14-27-2)20-18(12-24-22)25-17-10-7-11-19(21(17)20)29-13-15-8-5-4-6-9-15/h4-12,25H,3,13-14H2,1-2H3 |
| InChIKey | WFPXOWCKXUEKCA-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=NC=C2C(=C1COC)C3=C(N2)C=CC=C3OCC4=CC=CC=C4 |
| Reference | </br>1:CGS 9896 and ZK 91296, but not CGS 8216 and RO 15-1788, are pure benzodiazepine receptor antagonists on mouse neurons in culture. De Deyn PP, Macdonald RL.J Pharmacol Exp Ther. 1987 Jul;242(1):48-55. PMID: 3039114 </br>2:Discriminative stimulus properties of chlordiazepoxide and zolpidem. Agonist and antagonist effects of CGS 9896 and ZK 91296. Sanger DJ, Zivkovic B.Neuropharmacology. 1987 May;26(5):499-505. PMID: 3037419 </br>3:Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. Corda MG, Giorgi O, Longoni B, Mereu GP, Biggio G.J Neurochem. 1987 May;48(5):1355-8. PMID: 2881979 </br>4:Behavioral effects of the beta-carboline derivatives ZK 93423 and ZK 91296 in squirrel monkeys: comparison with lorazepam and suriclone. Wettstein JG, Spealman RD.J Pharmacol Exp Ther. 1987 Feb;240(2):471-5. PMID: 2879907 </br>5:Evidence that the beta-carboline, ZK 91296, can reduce anxiety in animals at doses well below those causing sedation. Pellow S, File SE.Brain Res. 1986 Jan 15;363(1):174-7. PMID: 2868775 </br>6:ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties. Klockgether T, Schwarz M, Turski L, Sontag KH.Eur J Pharmacol. 1985 Apr 16;110(3):309-15. PMID: 2861101 </br>7:Antiepileptic action of the beta-carboline ZK 91296 in a genetic petit mal model in rats. Jensen LH, Marescaux C, Vergnes M, Micheletti G, Petersen EN.Eur J Pharmacol. 1984 Jul 20;102(3-4):521-4. PMID: 6436039 </br>8:ZK 91296, a partial agonist at benzodiazepine receptors. Petersen EN, Jensen LH, Honoré T, Braestrup C, Kehr W, Stephens DN, Wachtel H, Seidelman D, Schmiechen R.Psychopharmacology (Berl). 1984;83(3):240-8. PMID: 6089246 </br>9:Anticonvulsant action in the photosensitive baboon, Papio papio, of a novel beta-carboline derivative, ZK 91296. Meldrum BS, Evans MC, Braestrup C.Eur J Pharmacol. 1983 Jul 22;91(2-3):255-9. PMID: 6311579 |
